Metabolic profiling of cell growth and death in cancer: applications in drug discovery

Boros LG, Cascante M, Lee W-NP (2002): Metabolic profiling of cell growth and death in cancer: applications in drug discovery. Drug Discovery Today. 7(6):18-26.
Abstract

Metabolic profiling using stable-isotope tracer technology enables the measurement of substrate redistribution within major metabolic pathways in living cells. This technique has been demonstrated that tranformed human cells exhibit profound metabolic shifts and that some and anti-cancer drugs produce their effects by forcing a reversion of these metabolic changes. By revealing tumor-specific metabolic shifts in tumor cells, metabolic profiling enables drug developers to identify the metabolic steps that control cell proliferation, thus aiding the identification of new anti-cancer targets and screening of lead compounds for anti-proliferative metabolic effects.

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