Fermented wheat germ extract (avemar) inhibits adjuvant arthritis
Á. Resetár, A. Telekes, B. Szende, E. Rásó, G. Bálint, G. Blazsó, Gy. Falkay, K. Lapis, M. Ehrenfeld, M. Hídvégi, Y. Shoenfeld
Annals of the New York Academy of Sciences, 2007
Abstract
Anti-inflammatory efficacy of the fermented wheat germ extract (FWGE, Avemar) in the rat adjuvant arthritis (AA) model was examined. To Wistar rats with AA, different doses of FWGE and anti-inflammatory drugs (indomethacin, dexamethasone) as monotherapies were administered and FWGE and either diclofenac or dexamethasone were also given in combination. Besides plethysmographies of the paws, histological investigations of synovial tissues were also performed along with detection of CD4+ and CD8+ T lymphocytes (»)
Effect of Avemar - a fermented wheat germ extract - on rheumatoid arthritis. Preliminary data
Á. Apáthy, A. Paksy, Á. Resetár, A. Telekes, B. Szende, G. Bálint, G. Blazsó, G. Falkay, M. Ehrenfeld, M. Gaál, M. Hídvégi, Y. Shoenfeld
Clinical and Experimental Rheumatology, 2006
Abstract
OBJECTIVE: To investigate the effect of the fermented wheat germ extract (Avemar) in patients with severe rheumatoid arthritis (RA). METHODS: Fifteen female RA (Steinbrocker II-III) patients, who had unsuccessfully tried two different DMARD treatments, were enrolled in an open-label, 1-year long, pilot clinical study. DMARD and steroid therapies were recorded and continued. All patients received Avemar as additional therapy. For measurement of efficacy the Ritchie Index, the Health Assessment Questionnaire (»)
Effect of simultaneous administration of Avemar and cytostatic drugs on viability of cell cultures, growth of experimental tumors, and survival tumor-bearing mice
A. Tompa, B. Szende, Z. marcsek, Zs. Kocsis
Cancer Biotherapy & Radiopharmaceuticals, 2004
Abstract
Avemar, a wheat germ preparation with immunomodulant and antimetastatic activity, was applied simultaneously with cytostatic drugs of different modes of action, in vitro and in vivo, in order to find out whether this simultaneous administration exerts an antagonistic or a synergistic effect on the viability of cell cultures, tumor growth, and survival of animals, inoculated with a transplantable mouse tumor (3LL-HH). In vitro, Avemar did not influence the effect on the viability of MCF-7, HepG2, or Vero cel (»)
The efficacy of tamoxifen in estrogen receptor-positive breast cancer cells is enhanced by a medical nutriment
A. Tompa, B. Szende, M. Jakab, Z. marcsek, Zs. Kocsis
Cancer Biotherapy & Radiopharmaceuticals, 2004
Abstract
Avemar, a fermented wheat germ extract, has been applied in the supplementary therapy of human cancers. Because tamoxifen is commonly used in the therapy of ER+ breast cancer, in this study the combined effect of tamoxifen and Avemar treatment was investigated on MCF-7 breast cancer cells, in order to detect a possible agonistic or antagonistic action. Cytotoxicity was measured by MTT assay, the percentage of mitoses and apoptotic cells was determined morphologically, apoptosis and S-phase was measured by f (»)
Chemoprevention with tamoxifen and Avemar by inducing apoptosis on MCF-7 (ER+) breast cancer cells
A. Tompa, B. Szende, M. Hídvégi, M. Jakab, Z. marcsek, Zs. Kocsis
2nd Congress of the World Society for Breast Health, 2003
Abstract
In the present study the combined effect of in vitro tamoxifen and Avemar treatment was studied on MCF-7 (ER+) breast cells as a model of a breast cancer situation. Cells were transformed for 24, 48 and 72 hours, cytotoxicity was measured by MTT assay, the percentage of apoptosis and cell proliferation was determined by flow cytometry, hematoxilin/cosin staining and by immunochemistry using the ApopTag reaction. Estrogen receptor activation was studied by semi-quantitative determination of the estr (»)
Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats
Á. Resetár, A. Telekes, A. Zalatnai, B. Szende, E. Rásó, K. Lapis, M. Hídvégi
Carcinogenesis, 2001
Abstract
It has been demonstrated for the first time that a wheat germ extract prevents colonic cancer in laboratory animals. Four-week-old inbred male F-344 rats were used in the study. Colon carcinogenesis has been induced by azoxymethane (AOM). Ten rats served as untreated controls (group 1). For the treatment of the animals in group 2, AOM was dissolved in physiologic saline and the animals were given three subcutaneous injections 1 week apart, 15 mg/kg body weight (b/w) each. In two additional groups Avemar (MS (»)
Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells
Á. Balogh, B. Szende, J. Boren, K. Lapis, L. G. Boros, M. Cascante, M. Hídvégi, R. Tömösköziné Farkas, S. Marin
Pancreas, 2001
Abstract
The fermented wheat germ extract with standardized benzoquinone composition has potent tumor propagation inhibitory properties. The authors show that this extract induces profound metabolic changes in cultured MIA pancreatic adenocarcinoma cells when the [1,2-13C2]glucose isotope is used as the single tracer with biologic gas chromatography-mass spectrometry. MIA cells treated with 0.1, 1, and 10 mg/mL wheat germ extract showed a dose-dependent decrease in cell glucose consumption, upt (»)
MSC, a new benzoquinone-containing natural product with antimetastatic effect
B. Szende, E. Rásó, J. Bocsi, K. Lapis, L. Prónai, M. Hídvégi, R. Tömösköziné Farkas, S. Paku
Cancer Biotherapy & Radiopharmaceuticals, 1999
Abstract
An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been (»)
Effect of Msc on the immune response of mice
B. Szende, E. Rásó, K. Lapis, M. Hídvégi, R. Tömösköziné Farkas
Immunopharmacology, 1999
Abstract
The supposed immunostimulatory actions of MSC, a new fermented wheat germ extract standardized to its benzoquinone composition (trade name: AVEMAR) were studied examining blastic transformation of peripheral blood lymphocytes of mice treated with MSC. It was found that MSC significantly increased the degree of blastic transformation caused by Concanavalin A. Using the B10LP to C57Bl skin graft system, MSC (0.03 and 3.0 g kg-1 applied orally) acted in favour of restoring the immune function. On th (»)
Effect of Avemar and Avemar + Vitamin C on tumor growth and metastasis in experimental animals
B. Szende, E. Rásó, K. Lapis, M. Hídvégi, R. Tömösközi-Farkas, S. Paku
Anticancer Research, 1998
Abstract
Because of the observed immunostimulatory actions of a new fermented wheat germ extract--with standardized benzoquinone composition--we have investigated the eventual tumor growth- and metastasis-inhibiting effects of this preparation (Avemar) applied alone or in combination with vitamin C. Tumor models of different origin [a highly metastatic variant of the Lewis lung carcinoma (3LL-HH), B16 melanoma, a rat nephroblastoma (RWT-M) and a human colon carcinoma xenograft (HCR25)]--kept in artificially immunosu (»)
A new benzoquinone-containing antimetastatic product
B. Szende, E. Rásó, J. Bocsi, K. Lapis, L. Prónai, M. Hídvégi, R. Tömösközi-Farkas, S. Paku
Hungarian Medical Journal (Orvosi Hetilap), 1998
Abstract
An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) was invented by Hungarian chemists under the trade--name of AVEMAR. The following biological effects of this product were observed. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes of mice. The same treatment shortens the survival time of skin grafts in co-isogenic mouse skin transplantation model, which points to immune-reconstructive effect of MSC. H (»)