Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis
A. Lackner, G. Graser, G. Krupitza, M. Fritzer-Szekeres, M. Grusch, M. Hídvégi, M. Ozsvar-Kozma, P. Saiko, R. P. Agrawal, S. Madlener, T. Szekeres, W. Jaeger
Oncology reports, 2009
Abstract
Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited the growth of sensitive H9 cells with IC50 values of 290 and 200 microg/ml, whereas the growth of 5-FdUrd/Ara-C cross-resistant H9 cells was attenuated with IC50 values o (»)