Potentials of the application of fermented wheat germ extract (Avemar) in the general practice
F. Elek
Medicus Universalis, 2006
The fermented wheat germ containing product enhances quality of life for patients with lung cancer
J. MOLDVAY, K. Lapis, M. Hídvégi, Z. AJKAY
Pulmono, 2003
Abstract
The quality of life of lung-cancer patients also afflicted with metastases is extremely poor, adversely affecting the efficiency of therapy as well as long-term survival. It is therefore particularly important to enhance the quality of life of these patients. Experiments have proven that Avemar, an oral product made from fermented wheat germ, has extremely powerful immune-modulation as well as tumour-inhibition effects. An open “pilot” clinical experiment has therefore been carried out in order to clarify w (»)
Avemar (Wheat germ extract) in Cancer Prevention and Treatment
A. Telekes, C. H. Chae, K. Vékey, M. Hegedűs
Nutrition and Cancer, 2009
Abstract
Many healthy foods are derived from wheat germ. The molecular composition of these products, however, greatly differs as shown by normal-phase HPLC-mass spectrometry analysis; thus, experimental data obtained by one of them is not necessarily true for the other. Avemar is a nontoxic wheat germ extract registered as a special nutriment for cancer patients in Hungary. It shows potent anticancer activity on cell lines by deeply interfering with glucose metabolism and affecting expressions of several kinases. I (»)
Promising cytotoxic activity profile of fermented wheat germ extract (Avemar) in human cancer cell lines
K. Jordan, T. Mueller, W. Voigt
Journal of Experimental and Clinical Cancer Research, 2011
Abstract
Fermented wheat germ extract (FWGE) is currently used as nutrition supplement for cancer patients. Limited recent data suggest antiproliferative, antimetastatic and immunological effects which were at least in part exerted by two quinones, 2-methoxy benzoquinone and 2,6-dimethoxybenzquinone as ingredients of FWGE. These activity data prompted us to further evaluate the in vitro antiproliferative activity of FWGE alone or in combination with the commonly used cytotoxic drugs 5-FU, oxaliplatin or irinotecan i (»)
Fermented Wheat Germ Extract (Avemar) in the Treatment of Cardiac Remodeling and Metabolic Symptoms in Rats
A. Iyler, L. Brown
Evidence-based Complementary and Alternative Medicine, 2009
Abstract
Avemar, a product of industrial fermentation of wheat germ with a standardized content of benzoquinone and plant flavonoids, has been tested as an anti-cancer and immunomodulatory dietary supplement. Proposed mechanisms include anti-oxidant and anti-inflammatory actions. This study has determined whether these actions of Avemar may also be useful in the treatment of cardiovascular diseases. Two experimental rat models of cardiovascular remodeling were used in this project: the deoxycorticosterone acetate (D (»)
Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis
A. Lackner, G. Graser, G. Krupitza, M. Fritzer-Szekeres, M. Grusch, M. Hídvégi, M. Ozsvar-Kozma, P. Saiko, R. P. Agrawal, S. Madlener, T. Szekeres, W. Jaeger
Oncology reports, 2009
Abstract
Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited the growth of sensitive H9 cells with IC50 values of 290 and 200 microg/ml, whereas the growth of 5-FdUrd/Ara-C cross-resistant H9 cells was attenuated with IC50 values o (»)
Unplugging Cancer's power supply
CCN, FACOG, Maureen Pelletier, MD
Anti-aging medical news, 2008
Abstract
Dr. Otto Warburg was awarded the Nobel Prize more than 70 years ago for his discovery that cancer cells use glucose at a rate 10 to 50 times higher than healthy cells through direct glycolys is via non-oxidative pathways. Called 'the Warburg Effect', this characteristic hypermetabolic activity fuels the explosive growth of cancer, steals glucose from healthy tissue and produces metabolic byproducts that contribute to systemic illness. Warburg theorized that if the uptake of glucose into cancer cells could b (»)
Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of high-risk skin melanoma patients: a randomized, pilot, phase II clinical study with a 7-year follow-up
E. V. Artamova, G. Y. Kharkevitch, L. V. Demiodov, L. V. Manzjuk, N. A. Pirogova
Cancer Biotherapy & Radiopharmaceuticals, 2008
Abstract
OBJECTIVE: The fermented wheat germ extract (FWGE) nutraceutical (Avemar), manufactured under "good manufacturing practice" conditions and, fulfilling the self-affirmed "generally recognized as safe" status in the United States, has been approved as a "dietary food for special medical purposes for cancer patients" in Europe. In this paper, we report the adjuvant use of this nutraceutical in the treatment of high-risk skin melanoma patients. METHODS: In a randomized, pilot, phase II clinical trial, the effic (»)
Fermented wheat germ extract
Memorial Sloan-Kettering
Integrative Medicine, 2007
Abstract
Fermented wheat germ extract (WGE) was developed by Mate Hidvegi, a Hungarian chemist, in the 1990s. It should not be confused with wheat germ oil. WGE is used as a dietary supplement by cancer patients in Hungary to improve quality of life. Results from in vitro studies show that WGE has anticancer, antimetastatic, and immunomodulatory effects. It was also shown to increase estrogen receptor (ER) activity in vitro. However, when used along with tamoxifen, an ER antagonist, it enhanced efficacy (»)
Fermented wheat germ extract (avemar) inhibits adjuvant arthritis
Á. Resetár, A. Telekes, B. Szende, E. Rásó, G. Bálint, G. Blazsó, Gy. Falkay, K. Lapis, M. Ehrenfeld, M. Hídvégi, Y. Shoenfeld
Annals of the New York Academy of Sciences, 2007
Abstract
Anti-inflammatory efficacy of the fermented wheat germ extract (FWGE, Avemar) in the rat adjuvant arthritis (AA) model was examined. To Wistar rats with AA, different doses of FWGE and anti-inflammatory drugs (indomethacin, dexamethasone) as monotherapies were administered and FWGE and either diclofenac or dexamethasone were also given in combination. Besides plethysmographies of the paws, histological investigations of synovial tissues were also performed along with detection of CD4+ and CD8+ T lymphocytes (»)
Efficacy of a medical nutriment in the treatment of cancer
F. Wang-Johanning, G. L. Johanning
Alternative Therapies, 2007
Abstract
Natural products are being used as supplements by cancer patients, with or without the knowledge of their cancer treatment team. It is important to know which of these products show efficacy against diseases such as cancer, and which are ineffective. It is also essential to define the mechanism(s) of action of natural products, especially as relevant to cancer prevention or treatment. The purpose of this article is to review the use of one such natural product, a fermented wheat germ extract (Avemar), in th (»)
Effect of Avemar - a fermented wheat germ extract - on rheumatoid arthritis. Preliminary data
Á. Apáthy, A. Paksy, Á. Resetár, A. Telekes, B. Szende, G. Bálint, G. Blazsó, G. Falkay, M. Ehrenfeld, M. Gaál, M. Hídvégi, Y. Shoenfeld
Clinical and Experimental Rheumatology, 2006
Abstract
OBJECTIVE: To investigate the effect of the fermented wheat germ extract (Avemar) in patients with severe rheumatoid arthritis (RA). METHODS: Fifteen female RA (Steinbrocker II-III) patients, who had unsuccessfully tried two different DMARD treatments, were enrolled in an open-label, 1-year long, pilot clinical study. DMARD and steroid therapies were recorded and continued. All patients received Avemar as additional therapy. For measurement of efficacy the Ritchie Index, the Health Assessment Questionnaire (»)
Avemar as a supportive therapy in cancer
Nancy Walsh
Internal Medicine News, 2006
Abstract
An extract of fermented wheat germ, Avemar, was developed during the 1990s by Hungarian biochemist Mate Hidvegi, Ph.D. Initially, Avemar was available as an over-the-counter dietary supplement, but in 2002 the product was registered as a medical nutriment with an indication for use in cancer treatment by the Hungarian National Institute of Food Safety and Nutrition.
“It is not like shark cartilage or cat’s claw or other such products, which may or may not be good, but which are not official cancer (»)
Avemar, a functional food with proven anti - cancer effects
Dan Kenner, LAc, Phd
Townsend Letter, 2006
Abstract
Avemar is concentrated and extracted from fermented wheat germ via a patented process and has been shown in cell, animal, and human clinical studies to have potent anti-cancer and immune system-modulating effects. Extensive published research supports the use of Avemar both as a medicament in its own right and as an adjuvant to conventional cancer therapy. (1-3) Avemar has proven effective against all cancer cell lines tested, including breast, prostate, lung, pancreatic, lymphoma, and leukemia. It has been (»)
Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells
A. Bernhaus, A. Lackner, G. Krupitza, K. Ammer, M. Fritzer-Szekeres, M. Grusch, M. Ozsvar-Kozma, P. Saiko, S. Madlener, T. Szekeres, W. Jaeger, Zs. Horváth
Cancer Letters, 2006
Abstract
Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with IC50 values of 400, 190, and 160 µg/ml, respectively. Incubation with MSC caused dose-dependent induction of apoptosis in up to 85% of tumor cells. In addition, Avemar attenuated th (»)
Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation
Á. Resetár, A. Telekes, E. Duda, E. E. Qwarnstrom, E. Kiss-Tóth, E. Kúsz, S. K. Dower, T. Nagy, T. polgár
Annals of the New York Academy of Sciences, 2005
Abstract
Macrophages activated by lipopolysaccharide and/or phorbol esters exhibited high sensitivity to Avemar, a fermented wheat germ extract. Avemar synergized with lipopolysaccharide and PMA in the induction of the transcription of cytokine genes and release of inflammatory cytokines. At higher concentrations the preparation had a significant negative effect on the proliferation and survival of activated myeloid cell types. Avemar treatment induced the synthesis of ICAM-1 and synergized with the ICAM-inducing ef (»)
Fermented wheat germ extract (Avemar) in the treatment of cancer and autoimmune diseases
L. G. Boros, M. Nichelatti, Y. Shoenfeld
Annals of the New York Academy of Sciences, 2005
Abstract
Avemar, the product of industrial fermentation of wheat germ, possesses unique cancer-fighting characteristics. Taken orally, Avemar can inhibit metastatic tumor dissemination and proliferation during and after chemotherapy, surgery, or radiation. Benefits of Avemar treatment have been shown in various human cancers, in cultures of in vitro grown cancer cells, in the prevention of chemical carcinogenesis, and also in some autoimmune conditions. This document reviews the clinical and experimental results obt (»)
Fermented wheat germ extract in the supportive therapy of colorectal cancer
F. Elek
Hungarian Medical Journal (Orvosi Hetilap), 2005
Abstract
The role of the product in the treatment of colorectal cancer is reviewed in the light of experimental and clinical results to date. The fermented wheat germ extract (code name: MSC, trade name: Avemar) registered as a dietary food for special medical purposes for cancer patients to complement the active oncotherapy, exerted a growth inhibitory effect in HCR-25 human colon carcinoma xenograft, and had a synergistic effect with 5-FU in mouse C-38 colorectal carcinoma. The product is capable of chemopreventio (»)
Effect of simultaneous administration of Avemar and cytostatic drugs on viability of cell cultures, growth of experimental tumors, and survival tumor-bearing mice
A. Tompa, B. Szende, Z. marcsek, Zs. Kocsis
Cancer Biotherapy & Radiopharmaceuticals, 2004
Abstract
Avemar, a wheat germ preparation with immunomodulant and antimetastatic activity, was applied simultaneously with cytostatic drugs of different modes of action, in vitro and in vivo, in order to find out whether this simultaneous administration exerts an antagonistic or a synergistic effect on the viability of cell cultures, tumor growth, and survival of animals, inoculated with a transplantable mouse tumor (3LL-HH). In vitro, Avemar did not influence the effect on the viability of MCF-7, HepG2, or Vero cel (»)