A metabolic hypothesis of cell growth and death in pancreatic cancer
L. G. Boros, V. L. W. Go, W. Paul Lee
Pancreas, 2002
Abstract
INTRODUCTION: Tumor cells, just as other living cells, possess the potential for proliferation, differentiation, cell cycle arrest, and apoptosis. There is a specific metabolic phenotype associated with each of these conditions, characterized by the production of both energy and special substrates necessary for the cells to function in that particular state. Unlike that of normal living cells, the metabolic phenotype of tumor cells supports the proliferative state.
AIM: To present the metabolic hypothes (»)
Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines
Á. Resetár, A. Telekes, Cs. Vizler, D. Demydenko, É. Monostori, G. Ion, M. Hídvégi, R. Fajka-Boja, R. Tömösközi-Farkas, Y. Shoenfeld
International Journal of Oncology, 2002
Abstract
The fermented wheat germ extract (code name: MSC, trade name: Avemar), with standardized benzoquinone content has been shown to inhibit tumor propagation and metastases formation in vivo. The aim of this study was to understand the molecular and cellular mechanisms of the anti-tumor effect of MSC. Therefore, we have designed in vitro model experiments using T and B tumor lymphocytic cell lines. Tyrosine phosphorylation of intracellular proteins and elevation of the intracellular Ca2+ concentrati (»)
Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells
B. Comín-Anduix, C. Callol-Massot, J. Boren, J. J. Centelles, J. L. Torres, L. G. Boros, M. Cascante, N. Angell, S. Bassilian, S. Marin
The Journal of Biological Chemistry, 2002
Abstract
The fermented extract of wheat germ, trade name Avemar, is a complex mixture of biologically active molecules with potent anti-metastatic activities in various human malignancies. Here we report the effect of Avemar on Jurkat leukemia cell viability, proliferation, cell cycle distribution, apoptosis, and the activity of key glycolytic/pentose cycle enzymes that control carbon flow for nucleic acid synthesis. The cytotoxic IC50 concentration of Avemar for Jurkat tumor cells is 0.2 mg/ml, and incre (»)
Antimetastatic effect of Avemar in high-risk melanoma patients
E. V. Artamova, G. Y. Kharkevitch, L. V. Demidov, L. V. Manzjuk, N. A. Pirogova
18th UICC International Cancer Congress, 2002
Abstract
A fermented wheat germ extract (MSC, Avemar) is a medical nutriment, which has been shown to support treatments in colorectal cancer. METHODS. In an open-label randomised pilot study we compared, in postsurgical adjuvant setting, the effect of dacarbazine plus an up to 12 months long continuous MSC administration (MSC study group, 22 patients) against dacarbazine treatment on its own (control group, 24 pts) on the progression-free survival of stage III malignant skin melanoma patients. RESULTS. At the end-p (»)
Experimental and clinical results with Avemar (a dried extract from fermented wheat germ) in animal cancer models and in cancer patients
M. Hídvégi, M. Nichelatti
Nőgyógyászati Onkológia, 2002
Abstract
In the late 1990's, reports were published about a biotech process by which a fermented wheat germ extract could be produced. The product, called Avemar, available as a water soluble granulate for oral consumption, has gained much attention from cancer researchers of several countries, like Israel, Hungary, the United States, England and Russia. Studies show biological activity of Avemar that may be useful for the treatment of neoplastic diseases, effects which can be well used in the treatment of certain i (»)
Metabolic Profiling of Cell Growth and Death in Cancer: Applications in Drug Discovery
L. G. Boros, M. Cascante, W. Paul Lee
Drug Discovery Today, 2002
Abstract
Metabolic profiling using stable-isotope tracer technology enables the measurement of substrate redistribution within major metabolic pathways in living cells. This technique has been demonstrated that tranformed human cells exhibit profound metabolic shifts and that some and anti-cancer drugs produce their effects by forcing a reversion of these metabolic changes. By revealing tumor-specific metabolic shifts in tumor cells, metabolic profiling enables drug developers to identify the metabolic steps that co (»)