Safety studies regarding a standardized extract of fermented wheat germ
E. Kennepohl, G. Semjén, Gy. Sebestyén, J. T. Heimbach
International Journal of Toxicology, 2007
Abstract
"Avemar pulvis" is a powder consisting of an aqueous extract of fermented wheat germ, with the drying aids maltodextrin and silicon dioxide, standardized to contain approximately 200 microg/g of the natural constituent 2,6-dimethoxy-p-benzoquinone. The results of toxicological and clinical studies of this product demonstrate its safety for its intended use as a dietary supplement ingredient in the United States. Avemar pulvis has been used in Hungary since 1998 and is approved in that country, as well as in (»)
Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation
Á. Resetár, A. Telekes, E. Duda, E. E. Qwarnstrom, E. Kiss-Tóth, E. Kúsz, S. K. Dower, T. Nagy, T. polgár
Annals of the New York Academy of Sciences, 2005
Abstract
Macrophages activated by lipopolysaccharide and/or phorbol esters exhibited high sensitivity to Avemar, a fermented wheat germ extract. Avemar synergized with lipopolysaccharide and PMA in the induction of the transcription of cytokine genes and release of inflammatory cytokines. At higher concentrations the preparation had a significant negative effect on the proliferation and survival of activated myeloid cell types. Avemar treatment induced the synthesis of ICAM-1 and synergized with the ICAM-inducing ef (»)
Fermented wheat germ extract in the supportive therapy of colorectal cancer
F. Elek
Hungarian Medical Journal (Orvosi Hetilap), 2005
Abstract
The role of the product in the treatment of colorectal cancer is reviewed in the light of experimental and clinical results to date. The fermented wheat germ extract (code name: MSC, trade name: Avemar) registered as a dietary food for special medical purposes for cancer patients to complement the active oncotherapy, exerted a growth inhibitory effect in HCR-25 human colon carcinoma xenograft, and had a synergistic effect with 5-FU in mouse C-38 colorectal carcinoma. The product is capable of chemopreventio (»)
Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients
A. Paksy, D. Schuler, E. Szabó, G. Borgulya, Gy. Fekete, J.Müller, M. Babosa, M. Garami, M. Hídvégi, P. Hauser
Journal of Pediatric Hematology/Oncology, 2004
Abstract
PURPOSE: An open-label, matched-pair (by diagnosis, stage of disease, age, and gender) pilot clinical trial was conducted to test whether the combined administration of the medical nutriment MSC (Avemar) with cytotoxic drugs and the continued administration of MSC on its own help to reduce the incidence of treatment-related febrile neutropenia in children with solid cancers compared with the same treatments without MSC. METHODS: Between December 1998 and May 2002, 22 patients (11 pairs) were enrolled in thi (»)
A medical nutriment has supportive value in the treatment of colorectal cancer
Á. Balogh, A. Hoffmann, Á. Mayer, A. Telekes, A. Vágvölgyi, F. Jakab, F. Szetntpétery, K. Lapis, L. Thurzó, M. Hídvégi, M. Nichelatti, P. Sápy, Y. Shoenfeld, Zs. Kahán
British Journal of Cancer, 2003
Abstract
Avemar (MSC) is a medical nutriment of which preclinical and observational clinical studies suggested an antimetastatic activity with no toxicity. This open-label cohort trial has compared anticancer treatments plus Avemar (9 g once daily) vs anticancer treatments alone in colorectal patients, enrolled from three oncosurgical centres; cohort allocation was on the basis of patients’ choice. Sixty-six colorectal cancer patients received MSC supplement for more than 6 months and 104 patients served as controls (»)
Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines
Á. Resetár, A. Telekes, Cs. Vizler, D. Demydenko, É. Monostori, G. Ion, M. Hídvégi, R. Fajka-Boja, R. Tömösközi-Farkas, Y. Shoenfeld
International Journal of Oncology, 2002
Abstract
The fermented wheat germ extract (code name: MSC, trade name: Avemar), with standardized benzoquinone content has been shown to inhibit tumor propagation and metastases formation in vivo. The aim of this study was to understand the molecular and cellular mechanisms of the anti-tumor effect of MSC. Therefore, we have designed in vitro model experiments using T and B tumor lymphocytic cell lines. Tyrosine phosphorylation of intracellular proteins and elevation of the intracellular Ca2+ concentrati (»)
First clinical data of a natural immunomodulator in colorectal cancer
A. Hoffmann, Á. Mayer, F. Jakab, M. Ehrenfeld
Hepato-Gastroenterology, 2000
Abstract
MSC (trade-name AVEMAR) is a per os applicable complex of multiple, biologically active molecules obtained from fermented wheat-germ extract. Preclinical studies suggest potent anti-metastatic activity and it has a favorable toxicity profile. It has been aimed in a pilot-scale, phase II clinical study to document whether or not MSC as a support to surgery or plus chemotherapy adds any therapeutic benefit compared to the same combination without MSC in colorectal cancer. METHODOLOGY: From 1998 to June 1999, (»)
AVEMAR (a new benzoquinone-containing natural product) administration interferes with the Th2 response in experimental SLE and promotes amelioration of the disease
M. Blank, M. Ehrenfeld, M. Hídvégi, Y. Shoenfeld
Lupus, 2001
Abstract
The potential of oral treatment with AVEMAR, a new benzoquinone-containing fermentation product of wheat germ, on features of experimental systemic lupus erythematosus (SLE) in naive mice, induced by idiotypic manipulation, was studied. We assessed the effect of AVEMAR on the profile of autoantibody production and the response of Th1/Th2 related cytokines as well as the clinical picture of experimental SLE in the SLE-induced mice. When the product was given in the pre-immunization period, down-regulation of (»)
Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells
Á. Balogh, B. Szende, J. Boren, K. Lapis, L. G. Boros, M. Cascante, M. Hídvégi, R. Tömösköziné Farkas, S. Marin
Pancreas, 2001
Abstract
The fermented wheat germ extract with standardized benzoquinone composition has potent tumor propagation inhibitory properties. The authors show that this extract induces profound metabolic changes in cultured MIA pancreatic adenocarcinoma cells when the [1,2-13C2]glucose isotope is used as the single tracer with biologic gas chromatography-mass spectrometry. MIA cells treated with 0.1, 1, and 10 mg/mL wheat germ extract showed a dose-dependent decrease in cell glucose consumption, upt (»)
MSC, a new benzoquinone-containing natural product with antimetastatic effect
B. Szende, E. Rásó, J. Bocsi, K. Lapis, L. Prónai, M. Hídvégi, R. Tömösköziné Farkas, S. Paku
Cancer Biotherapy & Radiopharmaceuticals, 1999
Abstract
An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been (»)
Effect of Msc on the immune response of mice
B. Szende, E. Rásó, K. Lapis, M. Hídvégi, R. Tömösköziné Farkas
Immunopharmacology, 1999
Abstract
The supposed immunostimulatory actions of MSC, a new fermented wheat germ extract standardized to its benzoquinone composition (trade name: AVEMAR) were studied examining blastic transformation of peripheral blood lymphocytes of mice treated with MSC. It was found that MSC significantly increased the degree of blastic transformation caused by Concanavalin A. Using the B10LP to C57Bl skin graft system, MSC (0.03 and 3.0 g kg-1 applied orally) acted in favour of restoring the immune function. On th (»)