Promising cytotoxic activity profile of fermented wheat germ extract (Avemar®) in human cancer cell lines
F. Reipisch, H.J. Schmoll, K. Jordan, K. Nerger, T. Mueller, W. Voigt
European Journal of Cancer Supplements, 2009
Abstract
Avemar is a fermented wheat germ extract with potent antimetastatic, antiproliferative and immunomodulatory activities. Chemically, it is a complex mixture of biologically active molecules including 2-methoxy-p-benzoquinone and 2,6-dimethoxy-p-benzoquinone which were supposed to be responsible for the main biological properties of Avemar. Despite its ubiquitous use as nutrition supplement for cancer patients in some countries only limited data are available on its activity in human cancer or in combination (»)
Immunologic and biochemical effects of the fermented wheat germ extract Avemar
A. Losert, C. Illmer, G. Krupitza, I. Herbacek, M. Fritzer-Szekeres, M. Grusch, P. Saiko, S. Madlener, T. Szekeres, Zs. Horváth
Experimental Biology and Medicine, 2005
Abstract
Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to have antitumor effects. Avemar has the potential to significantly improve the survival rate in patients suffering from malignant colon tumors. We studied its effects in the HT-29 human colon carcinoma cell line. Avemar had an inhibiting effect on colonies of HT-29 cells with an IC50 value of 118 lg/ml (7 days of incubation); this value could be decreased to 100 and 75 lg/ml in the presence of vitamin C. In the cell line examined, Ave (»)
Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats
Á. Resetár, A. Telekes, A. Zalatnai, B. Szende, E. Rásó, K. Lapis, M. Hídvégi
Carcinogenesis, 2001
Abstract
It has been demonstrated for the first time that a wheat germ extract prevents colonic cancer in laboratory animals. Four-week-old inbred male F-344 rats were used in the study. Colon carcinogenesis has been induced by azoxymethane (AOM). Ten rats served as untreated controls (group 1). For the treatment of the animals in group 2, AOM was dissolved in physiologic saline and the animals were given three subcutaneous injections 1 week apart, 15 mg/kg body weight (b/w) each. In two additional groups Avemar (MS (»)