Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis
A. Lackner, G. Graser, G. Krupitza, M. Fritzer-Szekeres, M. Grusch, M. Hídvégi, M. Ozsvar-Kozma, P. Saiko, R. P. Agrawal, S. Madlener, T. Szekeres, W. Jaeger
Oncology reports, 2009
Abstract
Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited the growth of sensitive H9 cells with IC50 values of 290 and 200 microg/ml, whereas the growth of 5-FdUrd/Ara-C cross-resistant H9 cells was attenuated with IC50 values o (»)
Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines
Á. Resetár, A. Telekes, Cs. Vizler, D. Demydenko, É. Monostori, G. Ion, M. Hídvégi, R. Fajka-Boja, R. Tömösközi-Farkas, Y. Shoenfeld
International Journal of Oncology, 2002
Abstract
The fermented wheat germ extract (code name: MSC, trade name: Avemar), with standardized benzoquinone content has been shown to inhibit tumor propagation and metastases formation in vivo. The aim of this study was to understand the molecular and cellular mechanisms of the anti-tumor effect of MSC. Therefore, we have designed in vitro model experiments using T and B tumor lymphocytic cell lines. Tyrosine phosphorylation of intracellular proteins and elevation of the intracellular Ca2+ concentrati (»)