Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells
A. Bernhaus, A. Lackner, G. Krupitza, K. Ammer, M. Fritzer-Szekeres, M. Grusch, M. Ozsvar-Kozma, P. Saiko, S. Madlener, T. Szekeres, W. Jaeger, Zs. Horváth
Cancer Letters, 2006
Abstract
Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with IC50 values of 400, 190, and 160 µg/ml, respectively. Incubation with MSC caused dose-dependent induction of apoptosis in up to 85% of tumor cells. In addition, Avemar attenuated th (»)
Immunologic and biochemical effects of the fermented wheat germ extract Avemar
A. Losert, C. Illmer, G. Krupitza, I. Herbacek, M. Fritzer-Szekeres, M. Grusch, P. Saiko, S. Madlener, T. Szekeres, Zs. Horváth
Experimental Biology and Medicine, 2005
Abstract
Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to have antitumor effects. Avemar has the potential to significantly improve the survival rate in patients suffering from malignant colon tumors. We studied its effects in the HT-29 human colon carcinoma cell line. Avemar had an inhibiting effect on colonies of HT-29 cells with an IC50 value of 118 lg/ml (7 days of incubation); this value could be decreased to 100 and 75 lg/ml in the presence of vitamin C. In the cell line examined, Ave (»)