Estudio de la eficacia del extracto de germen de trigo fermentado para el tratamiento del cáncer ovárico y definición de los fundamentos genómicos de su actividad
Ardeshir Hakam, Douglas C. Marchion, Dung-Tsa Chen, Elona Bicaku, Entidhar Al Sawah, Hye Sook Chon, Jesus Gonzalez-Bosquet, Johnathan M. Lancaster, Nadim Bou Zgheib, Patricia L. Judson, Robert M. Wenham, Sachin M. Apte, Xiaomang B. Stickles, Yin Xiong
International Journal of Gynecological Cancer, 2012
Abstracto
OBJETIVO: La mayoría de mujeres con cáncer epitelial de ovario (OVCA) en estadios avanzados terminan por desarrollar tumores recurrentes con quimiorresistencia. Por tanto, es muy necesario desarrollar agentes nuevos, más activos y menos tóxicos y/o optimizar la eficacia de los agentes ya existentes. MÉTODOS: En el presente estudio investigamos la actividad de Avemar, un extracto de germen de trigo fermentado (FWGE) natural y sin toxicidad, sobre una serie de líneas celulares de OVCA, tanto aisladamente com (»)
Prometedor perfil de actividad citotóxica del extracto de germen de trigo fermentado en líneas celulares cancerosas humanas
K. Jordan, T. Mueller, W. Voigt
Journal of Experimental and Clinical Cancer Research, 2011
Abstracto
El extracto de germen de trigo fermentado (FWGE, por sus siglas en inglés) se emplea comúnmente como alimento dietético en pacientes oncológicos. Algunos datos recientes sugieren sus efectos antiproliferativos, antimetástasis e inmunológicos, producidos al menos en parte por dos quinonas, la 2-metoxibenzoquinona y la 2,6-dimetoxibenzoquinona, componentes del FGWE. Estos datos de actividad nos incitaron a evaluar en mayor profundidad la actividad antiproliferativa in vitro del FGWE, por sí solo o (»)
Prometedor perfil de actividad citotóxica del extracto de germen de trigo fermentado en líneas celulares cancerosas humanas
F. Reipisch, H.J. Schmoll, K. Jordan, K. Nerger, T. Mueller, W. Voigt
European Journal of Cancer Supplements, 2009
Abstracto
Avemar is a fermented wheat germ extract with potent antimetastatic, antiproliferative and immunomodulatory activities. Chemically, it is a complex mixture of biologically active molecules including 2-methoxy-p-benzoquinone and 2,6-dimethoxy-p-benzoquinone which were supposed to be responsible for the main biological properties of Avemar. Despite its ubiquitous use as nutrition supplement for cancer patients in some countries only limited data are available on its activity in human cancer or in combination (»)
Avemar un extracto del germen de trigo fermentado, atenúa el crecimiento de células sensitivas y células H9 linfáticas humanas 5-FdUrd/Ara-C resistente cruzadas mediante del apoptosis.
A. Lackner, G. Graser, G. Krupitza, M. Fritzer-Szekeres, M. Grusch, M. Hídvégi, M. Ozsvar-Kozma, P. Saiko, R. P. Agrawal, S. Madlener, T. Szekeres, W. Jaeger
Oncology reports, 2009
Abstracto
Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited the growth of sensitive H9 cells with IC50 values of 290 and 200 microg/ml, whereas the growth of 5-FdUrd/Ara-C cross-resistant H9 cells was attenuated with IC50 values o (»)
Cambios en el panel de expresión de kinase de leukemia humano K562 después del tratamiento Avemar
A. Telekes, E. Rásó
Journal of Clinical Oncology, 2007
Abstracto
Background: The positive effect of the wheat germ extract Avemar has already been proved in cancer. Compared to the control group significantly longer survival times were achieved in both in vivo experiments and clinical studies. Inhibition of cell growth was also detected in K562 human leukaemia cell line in vitro. Avemar given p.o.(3 g/kg) resulted in significant increase of the survival time compared to the control group (p<0.005 Mann-Whitney) in i.v. implanted K562 xenograft model, which was practically (»)
Avemar, un extracto de germen de trigo fermentado non-tóxico, induce apoptosis e inhibe ribonucleotid reductasa en celulas de leucémicas promieloíticas humanas HL-60
A. Bernhaus, A. Lackner, G. Krupitza, K. Ammer, M. Fritzer-Szekeres, M. Grusch, M. Ozsvar-Kozma, P. Saiko, S. Madlener, T. Szekeres, W. Jaeger, Zs. Horváth
Cancer Letters, 2006
Abstracto
Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in human HL-60 promyelocytic leukemia cells. After 24, 48, and 72 h of incubation, Avemar inhibited the growth of HL-60 cells with IC50 values of 400, 190, and 160 µg/ml, respectively. Incubation with MSC caused dose-dependent induction of apoptosis in up to 85% of tumor cells. In addition, Avemar attenuated th (»)
Actividad citotóxica del extracto de germen de trigo fermentado (Avemar) en lás células con carcinoma gástrica humana mediante induciendo apoptosis
H. Park, K. E. Lee, S. N. Lee
Journal of Clinical Oncology, 2005
Abstracto
Background: The fermented wheat germ extract (code name:MSC, trade name: Avemar), is a complex mixture of biologically active molecules with potent anti-metastatic activities in various human malignancies. The objective of this study was to examine the in vitro cytotoxic activities of Avemar on 5 human gastric carcinoma cell lines and to test whether the mechanism involves induction of apoptosis. Methods: Cytotoxic activities of Avemar on 5 human gastric carcinoma cell lines (SNU-1, SNU-5, SNU-16, SNU-620, (»)
Efecto sinérgico de Avemar en la producción de citocina pro-inflamatoria y en la activación de las células Ras-activadas
Á. Resetár, A. Telekes, E. Duda, E. E. Qwarnstrom, E. Kiss-Tóth, E. Kúsz, S. K. Dower, T. Nagy, T. polgár
Annals of the New York Academy of Sciences, 2005
Abstracto
Macrophages activated by lipopolysaccharide and/or phorbol esters exhibited high sensitivity to Avemar, a fermented wheat germ extract. Avemar synergized with lipopolysaccharide and PMA in the induction of the transcription of cytokine genes and release of inflammatory cytokines. At higher concentrations the preparation had a significant negative effect on the proliferation and survival of activated myeloid cell types. Avemar treatment induced the synthesis of ICAM-1 and synergized with the ICAM-inducing ef (»)
Efectos inmunológicos y bioquímicos del extracto de germen de trigo fermentado (Avemar)
A. Losert, C. Illmer, G. Krupitza, I. Herbacek, M. Fritzer-Szekeres, M. Grusch, P. Saiko, S. Madlener, T. Szekeres, Zs. Horváth
Experimental Biology and Medicine, 2005
Abstracto
Avemar (MSC) is a nontoxic fermented wheat germ extract demonstrated to have antitumor effects. Avemar has the potential to significantly improve the survival rate in patients suffering from malignant colon tumors. We studied its effects in the HT-29 human colon carcinoma cell line. Avemar had an inhibiting effect on colonies of HT-29 cells with an IC50 value of 118 lg/ml (7 days of incubation); this value could be decreased to 100 and 75 lg/ml in the presence of vitamin C. In the cell line examined, Ave (»)
Efecto de la administración simultanea de Avemar y fármacos citotoxicos sobre la viabilidad de culturas celulares, crecimiento de tumores experimentales, y la sobrevivencia de ratas con tumores
A. Tompa, B. Szende, Z. marcsek, Zs. Kocsis
Cancer Biotherapy & Radiopharmaceuticals, 2004
Abstracto
Avemar, a wheat germ preparation with immunomodulant and antimetastatic activity, was applied simultaneously with cytostatic drugs of different modes of action, in vitro and in vivo, in order to find out whether this simultaneous administration exerts an antagonistic or a synergistic effect on the viability of cell cultures, tumor growth, and survival of animals, inoculated with a transplantable mouse tumor (3LL-HH). In vitro, Avemar did not influence the effect on the viability of MCF-7, HepG2, or Vero cel (»)
La eficacia del tamoxifeno en células tumorales mamarias con receptores estrogénicos positivos, mejorada por un alimento dietético
A. Tompa, B. Szende, M. Jakab, Z. marcsek, Zs. Kocsis
Cancer Biotherapy & Radiopharmaceuticals, 2004
Abstracto
Avemar, un extracto de germen de trigo fermentado, se ha empleado como terapia complementaria en cánceres humanos. Puesto que el tamoxifeno se utiliza normalmente para tratar el cáncer de mama ER+, en el presente estudio se investigó el efecto combinado del tratamiento con tamoxifeno y Avemar sobre células tumorales mamarias MCF-7, a fin de detectar una posible acción agonista o antagonista. La citotoxicidad se evaluó mediante la prueba MTT, la proporción de mitosis y células apoptóticas según criterios mor (»)
Quimioprevención con Tamoxifen y Avemar mediante la inducción del apoptosis en células cancerosas de mama MCF-7 (ER+)
A. Tompa, B. Szende, M. Hídvégi, M. Jakab, Z. marcsek, Zs. Kocsis
2nd Congress of the World Society for Breast Health, 2003
Abstracto
In the present study the combined effect of in vitro tamoxifen and Avemar treatment was studied on MCF-7 (ER+) breast cells as a model of a breast cancer situation. Cells were transformed for 24, 48 and 72 hours, cytotoxicity was measured by MTT assay, the percentage of apoptosis and cell proliferation was determined by flow cytometry, hematoxilin/cosin staining and by immunochemistry using the ApopTag reaction. Estrogen receptor activation was studied by semi-quantitative determination of the estr (»)
El papel quimiopreventivo de Avemar en la disminución del efecto citotóxico de los xenobióticos
Anna Tompa, Zoltán L. Marcsek, Zsuzsanna Kocsis
Journal of the International Society for Advanced Cytometry, 2003
Abstracto
The chemopreventive effect of AVEMAR, a new natural medicinal product dominantly composed of substituted benzochinon (2,6-dimethoxy-p-benzochinon), extracted from fermented wheat germ was studied. Earlier studies demonstrated that AVEMAR exhibits anti-metastatic, immunrestitutive, antioxidant properties, and able to increase apoptosis. The in vitro cytotoxic effect of AVEMAR was determined using the MTT assay on both normal (MRC-5) and transformed (Vero, HepG2, MCF-7, MDA-MB-231) cell lines. MCF-7 and He (»)
Un hipotesis metabólico de crecimiento y muerte celular en cáncer pancreático
L. G. Boros, V. L. W. Go, W. Paul Lee
Pancreas, 2002
Abstracto
INTRODUCTION: Tumor cells, just as other living cells, possess the potential for proliferation, differentiation, cell cycle arrest, and apoptosis. There is a specific metabolic phenotype associated with each of these conditions, characterized by the production of both energy and special substrates necessary for the cells to function in that particular state. Unlike that of normal living cells, the metabolic phenotype of tumor cells supports the proliferative state.
AIM: To present the metabolic hypothes (»)
Extracto germen de trigo fermentado induce apoptosis y descenso regulado del complejo mayor de histocompatibilidad de Clase-I en líneas celulares tumorosas de T y B
Á. Resetár, A. Telekes, Cs. Vizler, D. Demydenko, É. Monostori, G. Ion, M. Hídvégi, R. Fajka-Boja, R. Tömösközi-Farkas, Y. Shoenfeld
International Journal of Oncology, 2002
Abstracto
The fermented wheat germ extract (code name: MSC, trade name: Avemar), with standardized benzoquinone content has been shown to inhibit tumor propagation and metastases formation in vivo. The aim of this study was to understand the molecular and cellular mechanisms of the anti-tumor effect of MSC. Therefore, we have designed in vitro model experiments using T and B tumor lymphocytic cell lines. Tyrosine phosphorylation of intracellular proteins and elevation of the intracellular Ca2+ concentrati (»)
Extracto de germen de trigo fermentado inhibe las enzimas del ciclo glicolisis/pentosa e induce apoptosis mediante la actividad de la ensima poli-ADP ribosa polimerasa en celulas T de Jurkat con leucemia
B. Comín-Anduix, C. Callol-Massot, J. Boren, J. J. Centelles, J. L. Torres, L. G. Boros, M. Cascante, N. Angell, S. Bassilian, S. Marin
The Journal of Biological Chemistry, 2002
Abstracto
The fermented extract of wheat germ, trade name Avemar, is a complex mixture of biologically active molecules with potent anti-metastatic activities in various human malignancies. Here we report the effect of Avemar on Jurkat leukemia cell viability, proliferation, cell cycle distribution, apoptosis, and the activity of key glycolytic/pentose cycle enzymes that control carbon flow for nucleic acid synthesis. The cytotoxic IC50 concentration of Avemar for Jurkat tumor cells is 0.2 mg/ml, and incre (»)
Perfil metabólico de crecimiento y muerte celular en cáncer: Aplicaciones en el descubrimiento de fármacos
L. G. Boros, M. Cascante, W. Paul Lee
Drug Discovery Today, 2002
Abstracto
Metabolic profiling using stable-isotope tracer technology enables the measurement of substrate redistribution within major metabolic pathways in living cells. This technique has been demonstrated that tranformed human cells exhibit profound metabolic shifts and that some and anti-cancer drugs produce their effects by forcing a reversion of these metabolic changes. By revealing tumor-specific metabolic shifts in tumor cells, metabolic profiling enables drug developers to identify the metabolic steps that co (»)
Extracto de germen de trigo disminuye la captación de glucosa y la formación de RNA ribosa, pero aumenta la sintesis de ácido graso en celulás MIA pancreaticas adenocarcinomaticas
Á. Balogh, B. Szende, J. Boren, K. Lapis, L. G. Boros, M. Cascante, M. Hídvégi, R. Tömösköziné Farkas, S. Marin
Pancreas, 2001
Abstracto
The fermented wheat germ extract with standardized benzoquinone composition has potent tumor propagation inhibitory properties. The authors show that this extract induces profound metabolic changes in cultured MIA pancreatic adenocarcinoma cells when the [1,2-13C2]glucose isotope is used as the single tracer with biologic gas chromatography-mass spectrometry. MIA cells treated with 0.1, 1, and 10 mg/mL wheat germ extract showed a dose-dependent decrease in cell glucose consumption, upt (»)