El productos del germen de trigo fermentado mejora la calidad de vida de los pacientes con cáncer de pulmón
J. MOLDVAY, K. Lapis, M. Hídvégi, Z. AJKAY
Pulmono, 2003
Abstracto
The quality of life of lung-cancer patients also afflicted with metastases is extremely poor, adversely affecting the efficiency of therapy as well as long-term survival. It is therefore particularly important to enhance the quality of life of these patients. Experiments have proven that Avemar, an oral product made from fermented wheat germ, has extremely powerful immune-modulation as well as tumour-inhibition effects. An open “pilot” clinical experiment has therefore been carried out in order to clarify w (»)
Avemar un extracto del germen de trigo fermentado, atenúa el crecimiento de células sensitivas y células H9 linfáticas humanas 5-FdUrd/Ara-C resistente cruzadas mediante del apoptosis.
A. Lackner, G. Graser, G. Krupitza, M. Fritzer-Szekeres, M. Grusch, M. Hídvégi, M. Ozsvar-Kozma, P. Saiko, R. P. Agrawal, S. Madlener, T. Szekeres, W. Jaeger
Oncology reports, 2009
Abstracto
Avemar (MSC) is a nontoxic fermented wheat germ extract, which has been shown to significantly improve the survival rate in patients suffering from various malignancies. We investigated its effects in sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells. After 48 and 72 h of incubation, Avemar inhibited the growth of sensitive H9 cells with IC50 values of 290 and 200 microg/ml, whereas the growth of 5-FdUrd/Ara-C cross-resistant H9 cells was attenuated with IC50 values o (»)
Extracto de germen de trigo fermentado (Avemar) inhibe el artitis adyuvante
Á. Resetár, A. Telekes, B. Szende, E. Rásó, G. Bálint, G. Blazsó, Gy. Falkay, K. Lapis, M. Ehrenfeld, M. Hídvégi, Y. Shoenfeld
Annals of the New York Academy of Sciences, 2007
Abstracto
Anti-inflammatory efficacy of the fermented wheat germ extract (FWGE, Avemar) in the rat adjuvant arthritis (AA) model was examined. To Wistar rats with AA, different doses of FWGE and anti-inflammatory drugs (indomethacin, dexamethasone) as monotherapies were administered and FWGE and either diclofenac or dexamethasone were also given in combination. Besides plethysmographies of the paws, histological investigations of synovial tissues were also performed along with detection of CD4+ and CD8+ T lymphocytes (»)
Efecto de Avemar – un extracto de germen de trigo fermentado - en la Artitis Reumatoide. Datos prelinminados
Á. Apáthy, A. Paksy, Á. Resetár, A. Telekes, B. Szende, G. Bálint, G. Blazsó, G. Falkay, M. Ehrenfeld, M. Gaál, M. Hídvégi, Y. Shoenfeld
Clinical and Experimental Rheumatology, 2006
Abstracto
OBJECTIVE: To investigate the effect of the fermented wheat germ extract (Avemar) in patients with severe rheumatoid arthritis (RA). METHODS: Fifteen female RA (Steinbrocker II-III) patients, who had unsuccessfully tried two different DMARD treatments, were enrolled in an open-label, 1-year long, pilot clinical study. DMARD and steroid therapies were recorded and continued. All patients received Avemar as additional therapy. For measurement of efficacy the Ritchie Index, the Health Assessment Questionnaire (»)
Extracto de germen de trigo fermentado reduce el neutropenia febril, provocado por la quimioterapia, en los pacientes pediátricos con cáncer
A. Paksy, D. Schuler, E. Szabó, G. Borgulya, Gy. Fekete, J.Müller, M. Babosa, M. Garami, M. Hídvégi, P. Hauser
Journal of Pediatric Hematology/Oncology, 2004
Abstracto
PURPOSE: An open-label, matched-pair (by diagnosis, stage of disease, age, and gender) pilot clinical trial was conducted to test whether the combined administration of the medical nutriment MSC (Avemar) with cytotoxic drugs and the continued administration of MSC on its own help to reduce the incidence of treatment-related febrile neutropenia in children with solid cancers compared with the same treatments without MSC. METHODS: Between December 1998 and May 2002, 22 patients (11 pairs) were enrolled in thi (»)
Un alimento dietético válido para complementar el tratamiento del cáncer colorrectal
Á. Balogh, A. Hoffmann, Á. Mayer, A. Telekes, A. Vágvölgyi, F. Jakab, F. Szetntpétery, K. Lapis, L. Thurzó, M. Hídvégi, M. Nichelatti, P. Sápy, Y. Shoenfeld, Zs. Kahán
British Journal of Cancer, 2003
Abstracto
El MSC (Avemar) es un elemento nutritivo médico sobre el cual los estudios preclínicos y clínicos observacionales han sugerido que podría poseer actividad antimetástasis sin toxicidad. Este ensayo abierto de cohortes ha comparado tratamientos anticáncer y tratamientos anticáncer complementados con MSC (9 g dosis única diaria), en pacientes colorrectales procedentes de tres centros de cirugía oncológica; la asignación a las cohortes se realizó en base a los deseos de los pacientes. Sesenta y seis pacientes c (»)
Quimioprevención con Tamoxifen y Avemar mediante la inducción del apoptosis en células cancerosas de mama MCF-7 (ER+)
A. Tompa, B. Szende, M. Hídvégi, M. Jakab, Z. marcsek, Zs. Kocsis
2nd Congress of the World Society for Breast Health, 2003
Abstracto
In the present study the combined effect of in vitro tamoxifen and Avemar treatment was studied on MCF-7 (ER+) breast cells as a model of a breast cancer situation. Cells were transformed for 24, 48 and 72 hours, cytotoxicity was measured by MTT assay, the percentage of apoptosis and cell proliferation was determined by flow cytometry, hematoxilin/cosin staining and by immunochemistry using the ApopTag reaction. Estrogen receptor activation was studied by semi-quantitative determination of the estr (»)
Extracto germen de trigo fermentado induce apoptosis y descenso regulado del complejo mayor de histocompatibilidad de Clase-I en líneas celulares tumorosas de T y B
Á. Resetár, A. Telekes, Cs. Vizler, D. Demydenko, É. Monostori, G. Ion, M. Hídvégi, R. Fajka-Boja, R. Tömösközi-Farkas, Y. Shoenfeld
International Journal of Oncology, 2002
Abstracto
The fermented wheat germ extract (code name: MSC, trade name: Avemar), with standardized benzoquinone content has been shown to inhibit tumor propagation and metastases formation in vivo. The aim of this study was to understand the molecular and cellular mechanisms of the anti-tumor effect of MSC. Therefore, we have designed in vitro model experiments using T and B tumor lymphocytic cell lines. Tyrosine phosphorylation of intracellular proteins and elevation of the intracellular Ca2+ concentrati (»)
Resultados clínicos y experimentales con Avemar (un extracto seco de germen de trigo fermentado) en modelos animales de cáncer y en pacientes con cáncer
M. Hídvégi, M. Nichelatti
Nőgyógyászati Onkológia, 2002
Abstracto
In the late 1990's, reports were published about a biotech process by which a fermented wheat germ extract could be produced. The product, called Avemar, available as a water soluble granulate for oral consumption, has gained much attention from cancer researchers of several countries, like Israel, Hungary, the United States, England and Russia. Studies show biological activity of Avemar that may be useful for the treatment of neoplastic diseases, effects which can be well used in the treatment of certain i (»)
Extracto de germen de trigo fermentado inhibe la carciogénesis experimental de colon en ratas F-344
Á. Resetár, A. Telekes, A. Zalatnai, B. Szende, E. Rásó, K. Lapis, M. Hídvégi
Carcinogenesis, 2001
Abstracto
It has been demonstrated for the first time that a wheat germ extract prevents colonic cancer in laboratory animals. Four-week-old inbred male F-344 rats were used in the study. Colon carcinogenesis has been induced by azoxymethane (AOM). Ten rats served as untreated controls (group 1). For the treatment of the animals in group 2, AOM was dissolved in physiologic saline and the animals were given three subcutaneous injections 1 week apart, 15 mg/kg body weight (b/w) each. In two additional groups Avemar (MS (»)
Administración de Avemar (un nuevo producto natural, conteniendo benzoquinona) interfiere con la respuesta Th2 en SLE experimental y promueve el mejoramiento de la enfermedad
M. Blank, M. Ehrenfeld, M. Hídvégi, Y. Shoenfeld
Lupus, 2001
Abstracto
The potential of oral treatment with AVEMAR, a new benzoquinone-containing fermentation product of wheat germ, on features of experimental systemic lupus erythematosus (SLE) in naive mice, induced by idiotypic manipulation, was studied. We assessed the effect of AVEMAR on the profile of autoantibody production and the response of Th1/Th2 related cytokines as well as the clinical picture of experimental SLE in the SLE-induced mice. When the product was given in the pre-immunization period, down-regulation of (»)
Extracto de germen de trigo disminuye la captación de glucosa y la formación de RNA ribosa, pero aumenta la sintesis de ácido graso en celulás MIA pancreaticas adenocarcinomaticas
Á. Balogh, B. Szende, J. Boren, K. Lapis, L. G. Boros, M. Cascante, M. Hídvégi, R. Tömösköziné Farkas, S. Marin
Pancreas, 2001
Abstracto
The fermented wheat germ extract with standardized benzoquinone composition has potent tumor propagation inhibitory properties. The authors show that this extract induces profound metabolic changes in cultured MIA pancreatic adenocarcinoma cells when the [1,2-13C2]glucose isotope is used as the single tracer with biologic gas chromatography-mass spectrometry. MIA cells treated with 0.1, 1, and 10 mg/mL wheat germ extract showed a dose-dependent decrease in cell glucose consumption, upt (»)
MSC, un nuevo producto natural, conteniendo benzoquinona, con efectos antimetastaticos
B. Szende, E. Rásó, J. Bocsi, K. Lapis, L. Prónai, M. Hídvégi, R. Tömösköziné Farkas, S. Paku
Cancer Biotherapy & Radiopharmaceuticals, 1999
Abstracto
An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been (»)
Efecto de MSC sobre la respuesta inmunológica en ratas
B. Szende, E. Rásó, K. Lapis, M. Hídvégi, R. Tömösköziné Farkas
Immunopharmacology, 1999
Abstracto
The supposed immunostimulatory actions of MSC, a new fermented wheat germ extract standardized to its benzoquinone composition (trade name: AVEMAR) were studied examining blastic transformation of peripheral blood lymphocytes of mice treated with MSC. It was found that MSC significantly increased the degree of blastic transformation caused by Concanavalin A. Using the B10LP to C57Bl skin graft system, MSC (0.03 and 3.0 g kg-1 applied orally) acted in favour of restoring the immune function. On th (»)
Efecto de Avemar y Avemar + Vitamina C sobre el crecimiento de tumores y las metastasis en modelos experimentales
B. Szende, E. Rásó, K. Lapis, M. Hídvégi, R. Tömösközi-Farkas, S. Paku
Anticancer Research, 1998
Abstracto
Because of the observed immunostimulatory actions of a new fermented wheat germ extract--with standardized benzoquinone composition--we have investigated the eventual tumor growth- and metastasis-inhibiting effects of this preparation (Avemar) applied alone or in combination with vitamin C. Tumor models of different origin [a highly metastatic variant of the Lewis lung carcinoma (3LL-HH), B16 melanoma, a rat nephroblastoma (RWT-M) and a human colon carcinoma xenograft (HCR25)]--kept in artificially immunosu (»)
Un nuevo producto antimetastatico rico en benzoquinonas
B. Szende, E. Rásó, J. Bocsi, K. Lapis, L. Prónai, M. Hídvégi, R. Tömösközi-Farkas, S. Paku
Hungarian Medical Journal (Orvosi Hetilap), 1998
Abstracto
An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) was invented by Hungarian chemists under the trade--name of AVEMAR. The following biological effects of this product were observed. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes of mice. The same treatment shortens the survival time of skin grafts in co-isogenic mouse skin transplantation model, which points to immune-reconstructive effect of MSC. H (»)