The fermented wheat germ containing product enhances quality of life for patients with lung cancer
J. MOLDVAY, K. Lapis, M. Hídvégi, Z. AJKAY
Pulmono, 2003
Résumé
The quality of life of lung-cancer patients also afflicted with metastases is extremely poor, adversely affecting the efficiency of therapy as well as long-term survival. It is therefore particularly important to enhance the quality of life of these patients. Experiments have proven that Avemar, an oral product made from fermented wheat germ, has extremely powerful immune-modulation as well as tumour-inhibition effects. An open “pilot” clinical experiment has therefore been carried out in order to clarify w (»)
Extrait fermenté de germe de blé déclenche l'apoptose et le mécanisme de la régulation négative de la protéine du complexe majeur histocompatibilité classe I dans des lignées cellulaires T et B cancéreuses
Á. Resetár, A. Telekes, Cs. Vizler, D. Demydenko, É. Monostori, G. Ion, M. Hídvégi, R. Fajka-Boja, R. Tömösközi-Farkas, Y. Shoenfeld
International Journal of Oncology, 2002
Résumé
The fermented wheat germ extract (code name: MSC, trade name: Avemar), with standardized benzoquinone content has been shown to inhibit tumor propagation and metastases formation in vivo. The aim of this study was to understand the molecular and cellular mechanisms of the anti-tumor effect of MSC. Therefore, we have designed in vitro model experiments using T and B tumor lymphocytic cell lines. Tyrosine phosphorylation of intracellular proteins and elevation of the intracellular Ca2+ concentrati (»)
Premières données cliniques de l'immunomodulateur naturel dans le cancer colorectal
A. Hoffmann, Á. Mayer, F. Jakab, M. Ehrenfeld
Hepato-Gastroenterology, 2000
Résumé
MSC (trade-name AVEMAR) is a per os applicable complex of multiple, biologically active molecules obtained from fermented wheat-germ extract. Preclinical studies suggest potent anti-metastatic activity and it has a favorable toxicity profile. It has been aimed in a pilot-scale, phase II clinical study to document whether or not MSC as a support to surgery or plus chemotherapy adds any therapeutic benefit compared to the same combination without MSC in colorectal cancer. METHODOLOGY: From 1998 to June 1999, (»)
Extrait de germe de blé inhibit la carcinogenèse experimentale du côlon chez les rats F-344
Á. Resetár, A. Telekes, A. Zalatnai, B. Szende, E. Rásó, K. Lapis, M. Hídvégi
Carcinogenesis, 2001
Résumé
It has been demonstrated for the first time that a wheat germ extract prevents colonic cancer in laboratory animals. Four-week-old inbred male F-344 rats were used in the study. Colon carcinogenesis has been induced by azoxymethane (AOM). Ten rats served as untreated controls (group 1). For the treatment of the animals in group 2, AOM was dissolved in physiologic saline and the animals were given three subcutaneous injections 1 week apart, 15 mg/kg body weight (b/w) each. In two additional groups Avemar (MS (»)
Administration d'Avemar (un nouveau produit naturel, contenant de la benzoquinone) influence la réponse de Th2 dans le LED expérimental et aide l'amélioration de la maladie
M. Blank, M. Ehrenfeld, M. Hídvégi, Y. Shoenfeld
Lupus, 2001
Résumé
Le but de cette étude était d'examiner le potentiel du traitement oral d'Avemar (Avemar), un nouveau produit de fermentation à base de germe de blé, contenant de la benzoquinone, en cas de lupus érythémateux disséminé (LED) expérimentale induit chez des souris par manipulation idiotypique. Nous avons évalué l'effet d'Avemar sur le profil de la production des auto-anticorps et la réponse des cytokines Th1 / Th2 ainsi que le tableau clinique du lupus expérimentale chez les souris lupiques. Lorsque le produit (»)
Extrait de germe de blé diminue l’absorption du glucose et la formation de la ribose ARN mais augmente la synthèse des acides gras dans les cellules d'adénocarcinome pancréatique MIA
Á. Balogh, B. Szende, J. Boren, K. Lapis, L. G. Boros, M. Cascante, M. Hídvégi, R. Tömösköziné Farkas, S. Marin
Pancreas, 2001
Résumé
The fermented wheat germ extract with standardized benzoquinone composition has potent tumor propagation inhibitory properties. The authors show that this extract induces profound metabolic changes in cultured MIA pancreatic adenocarcinoma cells when the [1,2-13C2]glucose isotope is used as the single tracer with biologic gas chromatography-mass spectrometry. MIA cells treated with 0.1, 1, and 10 mg/mL wheat germ extract showed a dose-dependent decrease in cell glucose consumption, upt (»)
MSC, un nouveau produit naturel, contenant de la benzoquinone, avec des effets antimétastatiques
B. Szende, E. Rásó, J. Bocsi, K. Lapis, L. Prónai, M. Hídvégi, R. Tömösköziné Farkas, S. Paku
Cancer Biotherapy & Radiopharmaceuticals, 1999
Résumé
An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) has been invented by Hungarian chemists under the trade name of AVEMAR. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes in mice. The same treatment shortens the survival time of skin grafts in a co-isogenic mouse skin transplantation model, pointing to the immune-reconstructive effect of MSC. A highly significant antimetastatic effect of MSC has been (»)
Effets de MSC sur la réponse immunitaire chez les souris
B. Szende, E. Rásó, K. Lapis, M. Hídvégi, R. Tömösköziné Farkas
Immunopharmacology, 1999
Résumé
The supposed immunostimulatory actions of MSC, a new fermented wheat germ extract standardized to its benzoquinone composition (trade name: AVEMAR) were studied examining blastic transformation of peripheral blood lymphocytes of mice treated with MSC. It was found that MSC significantly increased the degree of blastic transformation caused by Concanavalin A. Using the B10LP to C57Bl skin graft system, MSC (0.03 and 3.0 g kg-1 applied orally) acted in favour of restoring the immune function. On th (»)
Effets d'Avemar et Avemar + vitamine C sur la croissance et les métastases du cancer chez les animaux experimentaux
B. Szende, E. Rásó, K. Lapis, M. Hídvégi, R. Tömösközi-Farkas, S. Paku
Anticancer Research, 1998
Résumé
Because of the observed immunostimulatory actions of a new fermented wheat germ extract--with standardized benzoquinone composition--we have investigated the eventual tumor growth- and metastasis-inhibiting effects of this preparation (Avemar) applied alone or in combination with vitamin C. Tumor models of different origin [a highly metastatic variant of the Lewis lung carcinoma (3LL-HH), B16 melanoma, a rat nephroblastoma (RWT-M) and a human colon carcinoma xenograft (HCR25)]--kept in artificially immunosu (»)
Nouveau produit antimétastatique contenant de la benzoquinone
B. Szende, E. Rásó, J. Bocsi, K. Lapis, L. Prónai, M. Hídvégi, R. Tömösközi-Farkas, S. Paku
Hungarian Medical Journal (Orvosi Hetilap), 1998
Résumé
An orally applicable fermentation product of wheat germ containing 0.04% substituted benzoquinone (MSC) was invented by Hungarian chemists under the trade--name of AVEMAR. The following biological effects of this product were observed. Oral administration (3 g/kg body weight) of MSC enhances blastic transformation of splenic lymphocytes of mice. The same treatment shortens the survival time of skin grafts in co-isogenic mouse skin transplantation model, which points to immune-reconstructive effect of MSC. H (»)