Please note Avemar is the original and inventor-approved brand of the world's first fermented wheat germ extract product. All clinical trials listed on this page were conducted exclusively with the authentic Avemar formulation—the exact product commercially available worldwide today.
Beware of imitations and any other fermented wheat germ extract brands: these use vastly different production methods yet falsely claim equivalence to Avemar by copying its studies without justification.
National Cancer Institute (USA) Drug Dictionary
Memorial Sloan Kettering Cancer Center (USA)
Extensive high-level clinical research in the United States has validated the efficacy of Avemar and sought to identify the specific molecular components responsible for its unique therapeutic benefits. Notably:
Dr. Máté Hidvégi, the inventor of Avemar, collaborated with Nobel laureate James D. Watson and colleagues at Cold Spring Harbor Laboratory to investigate Avemar’s mechanisms of action. Their research demonstrated that Avemar suppresses the Warburg effect, restores oxidative mitochondrial function, and inhibits tumor growth in vivo. A distinct fraction within Avemar, designated as 'A250', was identified as being responsible for these effects. Due to the extraction method, A250 is not available as a standalone product, but is 100% present within the orginal Avemar formulation.
At the University of California, Davies, Professor John Tuscano isolated specific protein fractions from Avemar and demonstrated their valuable immunomodulatory properties. These beneficial proteins are available when Avemar is consumed.
Ongoing, FDA-approved 100 patient clinical trial in UC Davies, Sacramento, California by Prof. Joseph Tuscano:
https://clinicaltrials.gov/study/NCT05967533
Case reports of cancer patients with hepatic metastases treated by standardized plant immunomodulatory preparations.
Hajtó T, Kirsch A
2013
J Cancer Res Updates. 2(1):1-9.
Adjuvant fermented wheat germ extract (Avemar) nutraceutical improves survival of high-risk skin melanoma patients: a randomized, pilot, phase II clinical study with a 7-year follow-up.
Demidov LV, Manziuk LV, Kharkevitch GY, Pirogova NA, Artamonova EV
2008
Cancer Biother Radiopharm. 23(4):477-82.
A multicentric prospective open trial on the quality of life and oxidative stress in patients affected by advanced head and neck cancer treated with a new benzoquinone-rich product derived from fermented wheat germ (Avemar).
Sukkar SG, Cella F, Rovera GM, Nichelatti M, Ragni G, Chiavenna G, Giannoni A, Ronzani G, Ferrari C
2008
Mediterranean J Nutr Metab. 1:37-42.
Effect of Avemar - a fermented wheat germ extract - on rheumatoid arthritis. Preliminary data.
Bálint G, Apáthy Á, Gaál M, Telekes A, Resetár Á, Blazsó G, Falkay G, Szende B, Paksy A, Ehrenfeld M, Shoenfeld Y, Hidvégi M
2006
Clin Exp Rheumatol. 24:325-8.
A Magyar Arc-, Állcsont- és Szájsebészeti Társaság állásfoglalása szájüregi daganatos betegek Avemarral történő szupportív kezelésének indokoltságáról.
Barabás J, Németh Z
2006
Orv Hetil. 147(35):1709-11.
Fermented wheat germ extract reduces chemotherapy-induced febrile neutropenia in pediatric cancer patients.
Garami M, Schuler D, Babosa M, Borgulya G, Hauser P, Müller J, Paksy A, Szabó E, Hidvégi M, Fekete G
2004
J Pediatr Hematol Oncol. 26(10):631-5.
A medical nutriment has supportive value in the treatment of colorectal cancer.
Jakab F, Shoenfeld Y, Balogh Á, Nichelatti M, Hoffmann A, Kahán Z, Lapis K, Mayer Á, Sápy P, Szetntpétery F, Telekes A, Thurzó L, Vágvölgyi A, Hidvégi M
2003
British Journal of Cancer. 89(3):465-9.
Fermentált búzacsíra tartalmú készítmény alkalmazásakor javul a tüdőrákos betegek életminősége.
Hidvégi M, Moldvay J, Lapis K, Ajkay Z
2003
Medicus Anonymus (Pulmono). 1:13-4.
First clinical data of a natural immunomodulator in colorectal cancer.
Jakab F, Mayer Á, Hoffmann A, Hidvégi M
2000
Hepatogastroenterology. 47:393-5.
AVEMAR IN VITRO CELL LINE STUDIES
2,6-Dimethoxy-1,4-benzoquinone Inhibits 3T3-L1 Adipocyte Differentiation via Regulation of AMPK and mTORC1.
Son HJ, Jang YJ, Jung CH, Ahn J, Ha TY
(2019)
Planta Med. 85: 210-216.
The Effects of Adjuvant Fermented Wheat Germ Extract on Cancer Cell Lines: A Systematic Review.
Zhurakivska K, Troiano G, Caponio VCA, Dioguardi M, Arena C, Muzio LL
(2018)
Nutrients. 10:1546.
Mechanism of the anti-angiogenic effect of Avemar on tumor cells.
Imir NG, Aydemir E, Şimşek E
(2018)
Oncol Lett. 15(2):2673-2678.
Antiproliferative and antimetabolic effects behind the anticancer property of fermented wheat germ extract.
Otto C, Hahlbrock T, Eich KPJ, Karaaslan F, Jürgens C, Germer C-T, Wiegering A, Kämmerer U
(2016)
BMC Complement Altern Med. 16:160 (10 pages). doi:10.1186/s12906-016-1138-5
Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of its activity.
Judson PL, Sawah EA, Marchion DC, Xiong Y, Bicaku E, Zgheib NB, Chon HS, Stickles XB, Hakam A, Wenham RM, Apte SM, Gonzalez-Bosquet J, Chen D-T, Lancaster JM:
(2012)
Int J Gynecol Cancer. 22(6):960-7.
Promising cytotoxic activity profile of fermented wheat germ extract (Avemar) in human cancer cell lines.
Mueller T, Jordan K, Voigt W
(2011)
J Exp Clin Cancer Res. 30:42. (7 pages).
Promising cytotoxic activity profile of fermented wheat germ extract (Avemar) in human cancer cell lines.
Voigt W, Mueller T, Jordan K, Reipisch F, Nerger K, Schmoll HJ
(2009)
Eur J Cancer. S7:110.
Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis.
Saiko P, Ozsvar-Kozma M, Graser G, Lackner A, Grusch M, Madlener S, Krupitza G, Jaeger W, Hidvégi M, Agarawal RP, Fritzer-Szekeres M, Szekeres T
(2009)
Oncol Rep. 21:787-91.
Changes in the kinase expression panel of K562 human leukemia after Avemar treatment.
Telekes A, Rásó E
(2007)
J Clin Oncol. 25(18):14143.
Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells.
Saiko P, Ozsvar-Kozma M, Madlener S, Bernhaus A, Lackner A, Grusch M, Horváth Z, Krupitza G, Jaeger W, Ammer K, Fritzer-Szekeres M, Szekeres T
(2006)
Cancer Lett. 250:323-8.
Cytotoxic activities of fermented wheat germ extract on human gastric carcinoma cells by induction of apoptosis.
Lee SN, Park H, Lee KE
(2005)
J Clin Oncol. 23(16):4254.
Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation.
Telekes A, Kiss-Tóth E, Nagy T, Qwarnstrom EE, Kúsz E, Polgár T, Resetár Á, Dower SK, Duda E
(2005)
Ann N Y Acad Sci. 1051:515–28.
Immunologic and biochemical effects of the fermented wheat germ extract Avemar.
Illmer C, Madlener S, Horváth Z, Saiko P, Losert A, Herbacek I, Grusch M, Krupitza G, Fritzer-Szekeres M, Szekeres T
(2005)
Exp Biol Med. (Maywood). 230:144-9.
The efficacy of tamoxifen in estrogen receptor–positive breast cancer cells is enhanced by a medical nutriment.
Marcsek Z, Kocsis Z, Jakab M, Szende B, Tompa A
(2004)
Cancer Biother Radiopharm. 19(6):746-53.
Effect of simultaneous administration of Avemar and cytostatic drugs on viability of cell cultures, growth of experimental tumors, and survival of tumor-bearing mice.
Szende B, Marcsek Z, Kocsis Z, Tompa A
(2004)
Cancer Biother Radiopharm. 19(3):343-9.
Chemoprevention with Tamoxifen and Avemar by inducing apoptosis on MCF-7 (ER+) Breast cancer cells.
Tompa A, Kocsis Z, Marcsek Z, Jakab M, Szende B, Hidvégi M
(2003)
In: 2nd Congress of the World Society for Breast Health. Monduzzi Editore, Bologna, p. 61-6.
Chemopreventive role of Avemar in decreasing the cytotoxic effect of xenobiotics.
Kocsis Z, Marcsek Z, Tompa A
(2003)
Journal of the International Society for Advanced Cytometry.
A metabolic hypothesis of cell growth and death in pancreatic cancer.
Boros LG, Lee W-NP, Go VLW
(2002)
Pancreas. 24(1):26-33.
Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines.
Fajka-Boja R, Hidvégi M, Shoenfeld Y, Ion G, Demydenko D, Tömösközi-Farkas R, Vizler C, Telekes A, Resetár Á, Monostori É (2002):
Int J Oncol. 20:563-70.
Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells.
Comín-Anduix B, Boros LG, Marin S, Boren J, Callol-Massot C, Centelles JJ, Torres JL, Agell N, Bassilian S, Cascante M (2002)
J Biol Chem. 277(48):46408-14.
Metabolic profiling of cell growth and death in cancer: applications in drug discovery.
Boros LG, Cascante M, Lee W-NP
(2002)
Drug Discovery Today. 7(6):18-26.
Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells.
Boros LG, Lapis K, Szende B, Tömösközi-Farkas R, Balogh Á, Boren J, Marin S, Cascante M, Hidvégi M
(2001)
Pancreas. 23(2):141–7.
AVEMAR IN VIVO ANIMAL STUDIES
A purified, fermented, extract of Triticum aestivum has lymphomacidal activity mediated via natural killer cell activation.
Barisone GA, O'Donnell RT, Ma Y, Abuhay MW, Lundeberg K, Gowda S, Tuscano JM
(2018)
PLoS ONE. 13(1).
A protein extract from fermented wheat germ promotes NK cell-mediated lymphoma eradication in mouse xenografts.
Barisone GA, Ma Y, Abuhay MW, O'Donnell RT, Lundeberg K, Gowda S, Murphy W, Tuscano JM
(2017)
J ImmunoTherapy Cancer. 5(Suppl 2):P306.
A fermentált búzacsíra kivonat (Avemar) antivirális hatásai macska AIDS-modellben.
Stercz B
(2012):
PHD Tudományos Napok 2012 (Semmelweis Egyetem).
Effect of fermented wheat germ extract on feline viruses (a pilot study).
Kövesdi V, Stercz B, Tompa A, Ongradi J
(2009)
Acta Microbiologica et Immunologica Hungarica.
Fermented wheat germ extract (Avemar) in the treatment of cardiac remodeling and metabolic symptoms in rats.
Iyer A, Brown L
(2009)
Evid Based Complement Alternat Med. 2011:508957.
Fermented wheat germ extract (Avemar) inhibits adjuvant arthritis.
Telekes A, Resetár Á, Bálint G, Blazsó G, Falkay G, Lapis K, Rásó E, Szende B, Ehrenfeld M, Shoenfeld Y, Hidvégi M
(2007)
Ann N Y Acad Sci. 1110:348-61.
Avemar inhibits the growth of mouse and human xenograft mammary carcinomas comparable to endocrine treatments.
Tejeda M, Gaál D, Szűcs I, Telekes A
(2007)
J Clin Oncol. 25(18):21132.
Wheat germ extract inhibits experimental colon carcinogenesis in F-344 rats.
Zalatnai A, Lapis K, Szende B, Rásó E, Telekes A, Resetár Á, Hidvégi M
(2001)
Carcinogenesis. 22(10):1649-52.
Avemar (a new benzoquinone-containing natural product) administration interferes with the Th2 response in experimental SLE and promotes amelioration of the disease.
Ehrenfeld M, Blank M, Shoenfeld Y, Hidvégi M
(2001)
Lupus. 10:622-7.
MSC, a new benzoquinone-containing natural product with antimetastatic effect.
Hidvégi M, Rásó E, Tömösközi-Farkas R, Szende B, Paku S, Prónai L, Bocsi J, Lapis K
(1999)
Cancer Biother Radiopharm. 14(4):277-89.
Effect of MSC on the immune response of mice.
Hidvégi M, Rásó E, Tömösközi-Farkas R, Lapis K, Szende B
(1999):
Immunopharmacology. 41:183-6.
Effect of Avemar and Avemar + Vitamin C on tumor growth and metastasis in experimental animals.
Hidvégi M, Rásó E, Tömösközi-Farkas R, Paku S, Lapis K, Szende B
(1998)
Anticancer Res. 18:2353-8.
AVEMAR REVIEW ARTICLES
A systematic review on the health effects of fermented wheat germ extract with emphasis on cancer
Muzeyyen Berkel Kasikci, Aline Issa, Nurcan Baglam, Emine Dincer, Amaury Gérard, Sumeyye Kabakci, Vasfiye Hazal Özyurt, Zsolt Zalán, Taner Şar, Burcu Gündüz Ergün, Christophe Chassard, Smilja Praćer, Guy Vergères and Mustafa Guzel
Frontiers in Nutrition
The medical use of wheatgrass: Review of the gap between basic and clinical applications.
Bar-Sela G, Cohen M, Ben-Arye E, Epelbaum R (2015):
Mini Rev Med Chem. 15:1002-10.
The Cytotoxic Effects of Wheat Germ Extract on Glioblastoma Cell Line.
Uğur Y
(2014)
Other thesis, TED ANKARA KOLEJİ.
Available at: http://tedprints.tedankara.k12.tr/562/
Fermented wheat germ extract - nutritional supplement or anticancer drug?
Mueller T, Voigt W
(2011)
Nutr J. 10:89. (6 pages).
Avemar (Wheat germ extract) in Cancer Prevention and Treatment.
Telekes A, Hegedűs M, Chae C-H, Vékey K
(2009)
Nutr Cancer. 61(6):891-9.
The role of antioxidant supplement in immune system, neoplastic, and neurodegenerative disorders: a point of view for an assessment of the risk/benefit profile.
Brambilla D, Mancuso C, Scuderi MR, Bosco P, Cantarella G, Lempereur L, Benedetto GD, Pezzino S, Bernardini R
(2008)
Nutr J. 7:29 (9 pages).
Safety studies regarding a standardized extract of fermented wheat germ.
Heimbach JT, Sebestyén G, Semjén G, Kennepohl E
(2007)
Int J Toxicol. 26:253-9.
Efficacy of a medical nutriment in the treatment of cancer.
Johanning GL, Wang-Johanning F
(2007)
Altern Ther Health Med. 13(2):56-65.
Pfeifer B: Avemar
Pfeifer B, Preiß J, Unger C, eds.
(2006)
Onkologie integrativ. Elsevier, Urban and Fischer, Munchen, p. 226-9.
Fermentált búzacsíra kivonat (Avemar) alkalmazásának lehetőségei a családorvosi gyakorlatban.
Farkas E
(2006)
Medicus Universalis. 39(1):19-31.
Fermented wheat germ extract (Avemar) in the treatment of cancer and autoimmune diseases.
Boros LG, Nichelatti M, Shoenfeld Y, Shoenfeld Y
(2005)
Ann N Y Acad Sci. 1051:529-42.
Szupportív kezelés fermentált búzacsíra-kivonattal colorectalis carcinomában.
Farkas E
(2005)
Orv Hetil. 146(37):1925-31.
Oxidative stress and nutritional prevention in autoimmune rheumatic diseases.
Sukkar SG, Rossi E
(2004)
Autoimmunity Reviews. 3(2004):199–206.
Experimental and clinical results with Avemar (a dried extract from fermented weath germ) in animal cancer models and in cancer patients.
Nichelatti M, Hidvégi M
(2002)
Nőgyógyászati Onkológia. 7:40-1.
Antimetastatic effect of Avemar in high-risk melanoma patients.
Demidov LV, Manziuk LV, Kharkevitch GY, Artamonova EV, Pirogova NA
(2002)
18th UICC International Cancer Congress.
Egy új, szubszituált benzokinon tartalmú antimetasztatikus készítmény.
Szende B, Rásó E, Hidvégi M, Tömösközi-Farkas R, Paku S, Prónai L, Bocsi J, Lapis K
(1998)
Orv Hetil. 139(48):2893-7.
AVEMAR GENERAL ARTICLES
Unplugging cancer's power supply.
Pelletier M
(2008)
Anti-Aging Medical News. Summer issue:188-90.
Wheat germ extract.
Cassileth BR, Yeung KS, Gubili J
(2007)
In: Herb-drug interactions in oncology. Cancer Center, New York NY and People’s Medical Publishing House–USA, Shelton CT, p. 694-6.
Avemar – a functional food with proven anti-cancer effect.
Kenner D
(2006)
Townsend Letter.
August/September issue:96-100.
Avemar as supportive therapy in cancer.
Walsh N
(2006)
Internal Medicine News. 39(13):35.
A cancer therapy out of the blue.
Williams DG
(2005)
Alternatives for the Health Conscious Individual. 11(3):17-24.
Is it really from heaven above? The cancer miracle that leaves healthy cells healthy.
Wright KM
(2005)
HSI Health Sciences Institute. December issue. (4 pages).
