Keresés eredménye: In vitro (Cell Line Studies)

Boros LG, Lapis K, Szende B, Tömösközi-Farkas R, Balogh Á, Boren J, Marin S, Cascante M, Hidvégi M (2001): Wheat germ extract decreases glucose uptake and RNA ribose formation but increases fatty acid synthesis in MIA pancreatic adenocarcinoma cells. Pancreas. 23(2):141–7.
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Comín-Anduix B, Boros LG, Marin S, Boren J, Callol-Massot C, Centelles JJ, Torres JL, Agell N, Bassilian S, Cascante M (2002): Fermented wheat germ extract inhibits glycolysis/pentose cycle enzymes and induces apoptosis through poly(ADP-ribose) polymerase activation in Jurkat T-cell leukemia tumor cells. J Biol Chem. 277(48):46408-14.
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Fajka-Boja R, Hidvégi M, Shoenfeld Y, Ion G, Demydenko D, Tömösközi-Farkas R, Vizler C, Telekes A, Resetár Á, Monostori É (2002): Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines. Int J Oncol. 20:563-70.
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Boros LG, Lee W-NP, Go VLW (2002): A metabolic hypothesis of cell growth and death in pancreatic cancer. Pancreas. 24(1):26-33.
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Boros LG, Cascante M, Lee W-NP (2002): Metabolic profiling of cell growth and death in cancer: applications in drug discovery. Drug Discovery Today. 7(6):18-26.
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Kocsis Z, Marcsek Z, Tompa A (2003): Chemopreventive role of Avemar in decreasing the cytotoxic effect of xenobiotics. Journal of the International Society for Advanced Cytometry.
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Tompa A, Kocsis Z, Marcsek Z, Jakab M, Szende B, Hidvégi M (2003): Chemoprevention with Tamoxifen and Avemar by inducing apoptosis on MCF-7 (ER+) Breast cancer cells. In: 2nd Congress of the World Society for Breast Health. Monduzzi Editore, Bologna, p. 61-6.
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Szende B, Marcsek Z, Kocsis Z, Tompa A (2004): Effect of simultaneous administration of Avemar and cytostatic drugs on viability of cell cultures, growth of experimental tumors, and survival of tumor-bearing mice. Cancer Biother Radiopharm. 19(3):343-9.
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Marcsek Z, Kocsis Z, Jakab M, Szende B, Tompa A (2004): The efficacy of tamoxifen in estrogen receptor–positive breast cancer cells is enhanced by a medical nutriment. Cancer Biother Radiopharm. 19(6):746-53.
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Illmer C, Madlener S, Horváth Z, Saiko P, Losert A, Herbacek I, Grusch M, Krupitza G, Fritzer-Szekeres M, Szekeres T (2005): Immunologic and biochemical effects of the fermented wheat germ extract Avemar. Exp Biol Med. (Maywood). 230:144-9.
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Telekes A, Kiss-Tóth E, Nagy T, Qwarnstrom EE, Kúsz E, Polgár T, Resetár Á, Dower SK, Duda E (2005): Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation. Ann N Y Acad Sci. 1051:515–28.
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Lee SN, Park H, Lee KE (2005): Cytotoxic activities of fermented wheat germ extract on human gastric carcinoma cells by induction of apoptosis. J Clin Oncol. 23(16):4254.
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Saiko P, Ozsvar-Kozma M, Madlener S, Bernhaus A, Lackner A, Grusch M, Horváth Z, Krupitza G, Jaeger W, Ammer K, Fritzer-Szekeres M, Szekeres T (2006): Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells. Cancer Lett. 250:323-8.
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Telekes A, Rásó E (2007): Changes in the kinase expression panel of K562 human leukemia after Avemar treatment. J Clin Oncol. 25(18):14143.
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Voigt W, Mueller T, Jordan K, Reipisch F, Nerger K, Schmoll HJ (2009): Promising cytotoxic activity profile of fermented wheat germ extract (Avemar) in human cancer cell lines . Eur J Cancer. S7:110.
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Saiko P, Ozsvar-Kozma M, Graser G, Lackner A, Grusch M, Madlener S, Krupitza G, Jaeger W, Hidvégi M, Agarawal RP, Fritzer-Szekeres M, Szekeres T (2009): Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis. Oncol Rep. 21:787-91.
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Mueller T, Jordan K, Voigt W (2011): Promising cytotoxic activity profile of fermented wheat germ extract (Avemar) in human cancer cell lines. J Exp Clin Cancer Res. 30:42. (7 pages).
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Judson PL, Sawah EA, Marchion DC, Xiong Y, Bicaku E, Zgheib NB, Chon HS, Stickles XB, Hakam A, Wenham RM, Apte SM, Gonzalez-Bosquet J, Chen D-T, Lancaster JM (2012): Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of its activity. Int J Gynecol Cancer. 22(6):960-7.
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Otto C, Hahlbrock T, Eich KPJ, Karaaslan F, Jürgens C, Germer C-T, Wiegering A, Kämmerer U (2016): Antiproliferative and antimetabolic effects behind the anticancer property of fermented wheat germ extract. BMC Complement Altern Med. 16:160 (10 pages). doi:10.1186/s12906-016-1138-5
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Zhurakivska K, Troiano G, Caponio VCA, Dioguardi M, Arena C, Muzio LL (2018): The Effects of Adjuvant Fermented Wheat Germ Extract on Cancer Cell Lines: A Systematic Review. Nutrients. 10:1546.
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Imir NG, Aydemir E, Şimşek E (2018): Mechanism of the anti-angiogenic effect of Avemar on tumor cells. Oncol Lett. 15(2):2673-2678.
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Son HJ, Jang YJ, Jung CH, Ahn J, Ha TY (2019): 2,6-Dimethoxy-1,4-benzoquinone Inhibits 3T3-L1 Adipocyte Differentiation via Regulation of AMPK and mTORC1. Planta Med. 85: 210-216.
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