Annals of the New York Academy of Sciences

The Annals of the New York Academy of Sciences is the oldest continuously published scientific serial in the United States and among the most cited of multidisciplinary scientific serials worldwide. Established in 1823, the Annals is the premier publication of the Academy, offering volumes of review articles in special topical areas and proceedings of conferences sponsored by the Academy as well as other scientific organizations.<br>

The Annals provides multidisciplinary perspectives on research of current interest in the scientific community and society at large. Although primarily focused in biomedicine and biology, the scope of the Annals extends into diverse fields such as psychology, anthropology, and philosophy. Edited in consultation with experts in their fields, the Annals provide a neutral forum for discourse within and across many institutions and disciplines.<br>
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Ann N Y Acad Sci
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Fermented wheat germ extract (avemar) inhibits adjuvant arthritis

Anti-inflammatory efficacy of the fermented wheat germ extract (FWGE, Avemar) in the rat adjuvant arthritis (AA) model was examined. To Wistar rats with AA, different doses of FWGE and anti-inflammatory drugs (indomethacin, dexamethasone) as monotherapies were administered and FWGE and either diclofenac or dexamethasone were also given in combination. Besides plethysmographies of the paws, histological investigations of synovial tissues were also performed along with detection of CD4+ and CD8+ T lymphocytes.

Synergistic effect of Avemar on proinflammatory cytokine production and Ras-mediated cell activation

Macrophages activated by lipopolysaccharide and/or phorbol esters exhibited high sensitivity to Avemar, a fermented wheat germ extract. Avemar synergized with lipopolysaccharide and PMA in the induction of the transcription of cytokine genes and release of inflammatory cytokines. At higher concentrations the preparation had a significant negative effect on the proliferation and survival of activated myeloid cell types.

Fermented wheat germ extract (Avemar) in the treatment of cancer and autoimmune diseases

Avemar, the product of industrial fermentation of wheat germ, possesses unique cancer-fighting characteristics. Taken orally, Avemar can inhibit metastatic tumor dissemination and proliferation during and after chemotherapy, surgery, or radiation. Benefits of Avemar treatment have been shown in various human cancers, in cultures of in vitro grown cancer cells, in the prevention of chemical carcinogenesis, and also in some autoimmune conditions. This document reviews the clinical and experimental results obtained with this extract so far.

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